Microtubule-based force generation
نویسندگان
چکیده
منابع مشابه
Mechanisms of force generation by end-on kinetochore-microtubule attachments.
Generation of motile force is one of the main functions of the eukaryotic kinetochore during cell division. In recent years, the KMN network of proteins (Ndc80 complex, Mis12 complex, and KNL-1 complex) has emerged as a highly conserved core microtubule-binding complex at the kinetochore. It plays a major role in coupling force generation to microtubule plus-end polymerization and depolymerizat...
متن کاملConserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions. How microtubule binding stimulates their ATPase and controls force generation is not understood. To address this fundamental question, we visualized microtubule-bound kinesin-1 and kinesin-3 motor domains at multiple steps in their ATPase cycles--including their nucleotide-f...
متن کاملA Mathematical Model for Force Generation at the Kinetochore-Microtubule Interface
In this paper we construct and analyze a mathematical model for kinetochore (Kt) motors operating at the chromosome/microtubule interface. Motor dynamics are modeled using a jump-diffusion process that incorporates biased diffusion due to the binding of microtubules (MTs) by Kt binder elements and thermal ratchet forces that arise when the polymer grows against the Kt plate. The resulting force...
متن کاملAn MBoC Favorite: Force generation by microtubule assembly/disassembly in mitosis and related movements
This article came out in December 1995, while I was a postdoctoral fellow in Tim Mitchison’s lab at University of California, San Francisco, and shortly after I had discovered that kinesins could regulate microtubule dynamics. The review was extraordinarily helpful for me in that it provided a perspective that significantly clarified my thinking about the means by which microtubule dynamics cou...
متن کاملForce generation by microtubule assembly/disassembly in mitosis and related movements.
In this article, we review the dynamic nature of the filaments (microtubules) that make up the labile fibers of the mitotic spindle and asters, we discuss the roles that assembly and disassembly of microtubules play in mitosis, and we consider how such assembling and disassembling polymer filaments can generate forces that are utilized by the living cell in mitosis and related movements.
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
سال: 2016
ISSN: 1939-5116
DOI: 10.1002/wnan.1428